Johns Hopkins University
This study will evaluate the pharmacokinetic effects of acute and chronic dosing of a hemp-based cannabidiol (CBD) topical lotion with low levels of delta-9-tetrahydrocannabinol (THC) in a sanitized and controlled environment.
Participants (N = 6) will complete an 7-day residential study using a high CBD/low D9-THC lotion. The lotion is applied to the participants' upper arms four times daily in a sanitized and controlled procedure that eliminates the potential for specimen contamination. Oral fluid (OF) is collected before and after application (six samples/day); blood and urine are collected once/day. On discharge day, participants provide an intentionally contaminated OF sample. Participants return after a 7-day washout to provide 4 additional OF specimens, one "clean" and three more intentionally contaminated sa…
Inclusion Criteria: * Have provided written informed consent * Be between the ages of 18 and 55 * Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests * Test negative for recent cannabis use in urine at the screening visit and again upon admission for the inpatient stay. * Test negative for other drugs of abuse, including alcohol, at the screening visit and again upon admission for the inpatient stay. * Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and…
CBD will be topically applied
THC will be topically applied
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