Interindividual Variability in the Effect of Premeal Almond Supplementation on Glycemic Control - a Double Crossover Study
Pennington Biomedical Research Center
Summary
The goal of this study is to learn whether eating a small serving of almonds before meals can improve blood sugar control in adults who have early signs of problems with blood sugar regulation. The main questions it aims to answer are: 1. Does eating almonds before a meal reduce the rise in blood sugar after eating? 2. Do some people consistently benefit more than others from eating almonds before meals?
Description
Large rises in blood sugar after eating are an early warning sign of type 2 diabetes, and simple dietary strategies may help lower this risk. This study aims to understand whether eating a small serving of almonds before meals can help reduce postprandial blood sugar levels in adults who are at increased risk for developing type 2 diabetes. Participants will take part in two phases of the study: one conducted in a research clinic to carefully measure short-term blood sugar responses, and another conducted while participants follow a provided diet at home over a longer period. Sometimes partici…
Eligibility
- Age range
- 25–50 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adults aged 25-50 years * Females over 40 years must have had a cycle in the last 6 months * Body mass index (BMI) at least 18.5 and at most 55.0 kg/m2 * Impaired blood glucose by at least one of the following criteria: * Fasting blood glucose at least 100 mg/dL (5.6 mmol/L) and less than 125 mg/dL (6.9 mmol/L) * HbA1c at least 5.7% and less than 6.5% * Willing and able to comply with study foods * Willing and able to ingest acetaminophen as part of study procedures * Able to read, speak, and understand English Exclusion Criteria: * Weight change ≥5% in past 6 months,…
Interventions
- Dietary SupplementPremeal almond ingestion
Premeal almond ingestion (18 g; \~100 kcal) 30 minutes prior to meal
Location
- Pennington Biomedical Research CenterBaton Rouge, Louisiana