University of California, Berkeley
The purpose of this study is to examine the impact of nasal spray treatment on Meibomian gland function and ocular surface health in symptomatic dry eye patients with mild to moderate Meibomian gland dysfunction (MGD).
Dry eye disease is a common condition that occurs when eyes do not produce enough tears or when the quality of the tears is poor causing tears to evaporate quickly off the eye. This can lead to symptoms such as dryness, burning, irritation, and/or blurred vision. Meibomian gland dysfunction is the most common cause of evaporative dry eye disease. The purpose of this study is to examine the impact of nasal spray treatment on Meibomian gland function and ocular surface health in symptomatic dry eye patients with mild to moderate Meibomian gland dysfunction (MGD). The nasal spray is FDA approved…
Inclusion Criteria: * Is 18 years of age and has full legal capacity to volunteer (no max age requirement) * Baseline Ocular Surface Disease Index (OSDI) \>13 * Has mild to moderate MGD * Has best corrected visual acuity of 20/40 or better * Has had an oculo-visual examination in the last two years * Is willing to continue other daily dry eye management regimen (e.g., warm compresses, and/or eyelid margin cleaning) * Is willing to discontinue other prescription medications for dry eye disease (DED) management * Is willing to stop any topical eye drops before all planned visits * Has read, und…
After meeting eligibility criteria and signing informed consent, participants will be dispensed a 3-month supply of varenicline 0.03mg/spray nasal solution. Participants will take the nasal spray home and spray once in each nostril twice daily for 3 months
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