Blast Overpressure Longitudinal Exposure Study (BLES)
Uniformed Services University of the Health Sciences
Summary
The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel. The main questions it aims to answer are: What advanced brain imaging changes are related to clinical presentation after low-level blast exposure? What are the relationships between low-level blast exposure and common groups of symptoms after concussion? Participants will: * Undergo advanced brain imaging * Answer questionnaires * Complete clinical tests * Provide blood, urine, and saliva samples * Wear blast sensors
Description
Participants in this observational study are active-duty U.S. Special Operations Forces personnel between the ages of 18 and 50. This study is designed to characterize the neurological and clinical effects associated with repeated low-level blast exposure (LLBE) in this population. Concerns have emerged that cumulative exposure to sub-concussive blast overpressure (BOP), even in the absence of a diagnosable concussion, may be associated with subtle changes in brain structure and function over time. Due to the nature of their operational and training environments, Special Operations Forces pers…
Eligibility
- Age range
- 18–50 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Active duty * U.S. SOF personnel * 18-50 years old Exclusion Criteria: * Subjects will be excluded only if their participation will significantly interfere with validity of data collection or safety during the study (e.g., they have conditions that might result in harm or injury during research procedures). * Example: pregnancy (balance considerations) * Example: being unable to undergo MRI testing (i.e., they have non-MRI compatible devices, imbedded metal fragments such as shrapnel, and/or severe claustrophobia; these MRI contraindications will be screened using an M…
Locations (3)
- Walter Reed National Military Medical CenterBethesda, Maryland
- Fort BraggFort Bragg, North Carolina
- Wilford Hall Ambulatory Surgical CenterSan Antonio, Texas