Association Between Epigenetic Changes, Periodontal Microbiota, And Periodontal Inflammation in Obese Individuals
Louisiana State University Health Sciences Center in New Orleans
Summary
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are: • To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.
Description
Periodontitis is an inflammatory disease process primarily caused by microorganisms, which affects the tooth-supporting structures and can eventually lead to tooth loss. Oral health is a reflection of general health. Accordingly, obesity can influence periodontitis and increase its severity. The study participants will be categorized into two groups as described above. Enrolled participants will be balanced for distribution of age, gender, ethnicity, and general health. The objective of this pilot study is to investigate the cross-sectional and longitudinal changes in host epigenetic modifica…
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adults aged ≥18 years, * No history of periodontal therapy in the last 6 months, * No use of tobacco, * No history of pregnancy lactation or contraceptive medication. * Need to have a minimum of 20 teeth. Exclusion Criteria: * Had antimicrobial/antiviral therapy in the previous 3 months, * History of uncontrolled diabetes, * History of rheumatoid arthritis, * History of osteoporosis, * History of oral cancer, * Currently taking hormonal contraception, * If pregnant or lactating currently or prior 6 months, * Subjects on current weight loss drugs * If planning weight re…
Interventions
- ProcedureNon-surgical periodontal therapy will be administered
Non-surgical periodontal therapy (Deep cleaning-SRP): The deep cleaning by a scaling and root planing (SRP) procedure, is the standard initial treatment for all individuals diagnosed with periodontitis (periodontal disease). At the initial treatment planning appointment, each subject will receive intra-oral and extra-oral examination along with full mouth examination of the periodontal status, followed by diagnosis and treatment planning. The subject will then be scheduled for a deep cleaning procedure. The Deep cleaning procedure are carried out using hand instruments and ultrasonic instruments.
Location
- LSU Health Science Centre, School of DentistryNew Orleans, Louisiana