Crownlands Observing Progression With Neurons I (CROWN-I)
Crownlands
Summary
The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The primary objective is to identify the molecular and genetic modules that differentiate patient subtypes and predict progression of AD. Participants will visit clinical sites to donate samples multiple times and perform virtual and in-person clinical assessments.
Description
Neurological diseases are difficult to characterize at the molecular level because disease-relevant tissue is rarely available in clinical practice. As a result, precision approaches in neurology have historically relied on indirect measures, including clinical assessments, neuroimaging, and biomarkers measured in blood, cerebrospinal fluid (CSF), and other biofluids. Although these tools have advanced diagnosis and monitoring, they provide limited access to neuron-specific and high-dimensional molecular information. CROWN-I is a data-intensive longitudinal observational study designed to exp…
Eligibility
- Age range
- 55+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Informed consent provided by the participant or, where applicable, Legally Authorized Representative (LAR) or other substitute decision-maker where permitted by applicable law, as described in Section 8.2. * Male or female, age ≥ 55 years at Screening. * Fluency of subject and study partner in English sufficient to complete all cognitive and self-report assessments without interpreter assistance. * Adequate visual and auditory acuity (with correction permitted) sufficient to complete neuropsychological testing. * Not pregnant or lactating. * Medications stable ≥ 4 weeks…
Location
- Capital NeurologyGermantown, Maryland