Milton S. Hershey Medical Center
This project seeks to determine how e-cigarette (EC) physical design features, including those that allow the user to manipulate the quality and quantity of aerosols, affect exposure and toxicity from oxidants and other aerosol constituents.
Subjects will be provided with a study e-cigarette and e-liquid to use during the duration of the study. They will be asked to complete various questionaries as well as provide blood, exhaled breath, exhaled breath condensate, saliva and buccal cell samples. Their puffing behavior and biomarkers of tobacco exposure and harm will be measured as follows: E-cigarette (EC) puffing behavior - In order to determine a measurement of toxicant dose, topography markers such as puff duration, number of puffs, and interpuff interval (IPI) will be assessed via video recorded sessions. E-liquid consumpti…
Inclusion Criteria: * 21 years of age or older * Normal pulmonary and cardiovascular function with no history of COPD or cardiovascular disease (excluding hypertension) * Current exclusive use of a sub-ohm/mod or pod EC devices (≥ 1mL e-liquid/per day, ≥6 mg/ml nicotine concentration, EC for ≥ 1 year) * No plan on quitting nicotine use over the course of the study * All other forms of nicotine must be used \<5 days out of the past 28 days. * Able to read and write in English * Have access to email and a smartphone/computer that has reliable internet connection Exclusion Criteria: * Women wh…
Study provided electronic cigarette will be set to a high wattage resulting in a higher usage temperature (275 C)
Study provided electronic cigarette will be set to a low wattage resulting in a lower usage temperature (200 C)
Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (90%)
Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (10%)
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