Pilot Study: Dorsal Root Ganglion Stimulation After Spinal Cord Injury-Related Lower Motor Neuron Damage
Peter J. Grahn, Ph.D.
Summary
The purpose of this study is to study sensorimotor circuit activity generated in response to temporarily implanted dorsal root ganglion stimulation by recording from muscles of the lower extremities as well as functional outcomes achieved over a 10-day rehabilitation program in an individual with lower motor neuron injury.
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Traumatic and non-traumatic spinal cord injury (SCI) * ASIA Impairment Scale (AIS) A-D * SCI below the tenth thoracic vertebral level * Greater than 1 year post-SCI * Intact spinal reflexes at or below injury level in 1 or more muscles Exclusion Criteria: * Currently a prison inmate, or awaiting trial, related to criminal activity * Pregnancy at the time of screening for trial enrollment * Active, untreated urinary tract infection * Unhealed decubitus ulcer * Unhealed skeletal fracture * Spinal abnormality that may impede percutaneous implantation of spinal electrodes…
Interventions
- DeviceAbbot Dorsal Root Ganglion Neurostimulator
After temporary implantation of leads into the dorsal root ganglia of lower spine, the patient will undergo 2-3 hour sessions over 10 days. Each session will consist of rehabilitation exercises will receiving electrical spinal stimulation.
Location
- Mayo ClinicRochester, Minnesota