Magnetic Resonance Imaging (MRI)-Based Quantification of Perfusion and Microstructure
University of Wisconsin, Madison
Summary
This study integrates and evaluates a series of novel MRI methods for quantifying blood perfusion and tissue microstructure. The proposed perfusion and microstructure measures may provide biomarkers for fibrosis, cirrhosis, portal hypertension, and response to treatment. The precision of these methods will be evaluated in 110 participants, including healthy volunteers, people with chronic liver disease (CLD), and people with liver fibrosis.
Description
The overall goal of this project is to develop a next-generation, confounder-corrected Intravoxel incoherent motion (IVIM)-MRI method for quantification of tissue perfusion and microstructure, and to validate this method in patients with CLD. This protocol will address these unmet needs through the following specific aims: Aim 1: Develop and optimize confounder-corrected IVIM to enable precise quantification over the entire liver. Aim 2: Validate the technical and clinical performance of confounder-corrected IVIM in patients with CLD. Aim 3: Demonstrate confounder-corrected IVIM as a marker…
Eligibility
- Age range
- 7+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria (Healthy Volunteers): * Age 7 years or older * Willing and able to complete study procedures Exclusion Criteria (Healthy Volunteers): * Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc) * Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening) * Received ferumoxytol injection within previous one year (clinical or research) * Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be al…
Interventions
- DeviceNovel MRI Software
* Each study visit will last approximately 2 hours * The visit will include approximately 1 hour of MR imaging * Participants will be asked to fast for 5 hours prior to the research visit
- OtherEnsure Plus Nutrition Shake
A subset of participants (N=15 with portal hypertension and N=15 without portal hypertension) from the Liver Fibrosis Cohort will be imaged in the fasted state, then exit the scanner where they will be asked to drink two Ensure Plus Nutrition shake. After a 20-minute delay, each subject will re-enter the scanner for additional imaging.
Location
- University of WisconsinMadison, Wisconsin