Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions - A Randomized Trial (DESTINATION 2)
Memorial Sloan Kettering Cancer Center
Summary
The purpose of this study is to see whether giving a lower (de-escalated) dose of radiation therapy to some parts of the prostate can reduce side effects compared to giving the same (uniform) dose of radiation therapy to the whole prostate.
Eligibility
- Age range
- 18+ years
- Sex
- Male
- Healthy volunteers
- No
Inclusion Criteria: * Documentation of Disease o Patients must have pathologically confirmed prostate adenocarcinoma. * Definition of Disease * Grade Group (GG) 1, 2, or 3. * PSA less than 20 ng/mL prior to starting ADT, if used. * Clinical stage of TX, T1 or T2 on digital rectal examination. May have up to radiological stage T3a on MRI. MRI must be performed within 12 months of randomization. * MRI-visible tumor(s), all having PIRADS v2.1 scores of 3, 4, or 5. Each tumor should be able to be delineated on T2 and diffusion-weighted imaging (DWI) +/- dynamic contrast-enhanced imagi…
Interventions
- RadiationMR-guided Stereotactic Body Radiation Therapy
MR-guided 2 fraction Stereotactic Body Radiation Therapy
Locations (7)
- Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey
- Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)Middletown, New Jersey
- Memorial Sloan Kettering at Bergen (Limited Protocol Activities)Montvale, New Jersey
- Memorial Sloan Kettering at Suffolk-Commack (Limited Protocol Activities)Commack, New York
- Memorial Sloan Kettering at Westchester (Limited Protocol Activities)Harrison, New York
- Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York