Indiana University
The goal of this study is to determine how much effect turning off an individual's Gastric Electrical Stimulator (GES) for up to four hours will have on levels of insulin, C-peptide, GLP-1 and glucose levels.
Up to thirty-two adult patients with gastroparesis who have undergone implantation of a gastric stimulation device at least three months prior may participate in this study, which will be completed at a single study visit. The study consists of two groups, an EXPERIMENTAL group that undergoes turning off the GES and a CONTROL group that does not undergo the turning off of the GES. The subjects are randomized to either the control or experimental group. After an overnight fast, consented and eligible patients are placed in the supine position on a hospital bed, and an intravenous line is inse…
Inclusion Criteria: * At least 18 years of age. * Documented diagnosis of gastroparesis * Not taking diabetic prescribed exogenous insulin. * Patient has a GES device that has been implanted for at least 3 months. * Willing to give up to 8 blood samples. * Willing to lie in a bed for up to 5.5 hours. Exclusion Criteria: * Pregnancy * History of allergic reaction to EKG lead placement adhesives. * Unable to give informed consent. * Unwilling to give up to 8 5 ml blood samples. * Unwilling to lie in a bed for up to 5.5 hours.
Device will either be turned off for the duration of the experimental period.
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