Memorial Sloan Kettering Cancer Center
The purpose of this study is to test the safety of MSK-TCR5 in participants with advance solid tumor cancer that has a KRAS, HRAS, or NRAS G12D mutation.
Inclusion Criteria: Part A: Prior to cell collection all of the following inclusion criteria must be met: * Age ≥18 years. * Histologically confirmed advanced or metastatic, unresectable solid tumor * Positive for RAS G12D mutation and HLA-A\*11:01 allele * Subject has advanced solid cancer, defined as unresectable, advanced, and/or metastatic disease after at least 1 line of systemic standard of care (SOC) treatment regimen and for which there are no available curative treatment options. Subjects with stable disease (SD), or that present lack of clinical benefit from previous therapy (inclu…
MSK-TCR5, created in participant-derived T cells and autologously reinfused into eligible participants following lymphodepleting chemotherapy