Effect of External Pressure and Muscle Contraction on Soft Tissue Oxygenation Measured With Functional MRI
Icahn School of Medicine at Mount Sinai
Summary
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
Description
Participant will undergo a single MRI examination. Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a standard brace soft foam attached; blood pressure cuff will be partially inflated. Participant will also be asked to lift MRI compatible 10 lb. weight. Muscle oxygenation will be actively measured using MRI. No medications are being given, and no invasive devices are being used.
Eligibility
- Age range
- 20–64 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Alert and oriented. * Able to lift 10lbs. and hold for 30 seconds * Not claustrophobic. * Intact sensation in right upper extremity. Exclusion Criteria: * Latex allergy or allergy to isopropyl alcohol. * Skin injury or decreased sensation on right upper extremity.
Interventions
- OtherCompression and Contraction
Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight.
Location
- Mount Sinai Hess CenterNew York, New York