Wright State University
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). The hypothesis to be tested in this study is that treatment with a single dose of 75mg of amitriptyline will block the MVP released from the skin from a very small localized burn injury.
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). Studies suggest these MVP are involved in many conditions such as after the thermal burn injury. In fact, there is evidence suggesting that these MVP cause severe toxic effects and could be responsible for deaths following extensive thermal burn injuries. These particles are typically found in skin and are evaluated by taking a portion of area with skin biopsy. Of importance, MVP release from the skin can be blocked by drugs such as amitriptyline, a medicine which is a tr…
Inclusion Criteria: * Adult Males and Females age 18 - 60 * All skin types on Fitzpatrick Scale (Type I-VI) * Able to comprehend procedures and risks * Willing to participate and understand the informed consent document * Have reliable transportation Exclusion Criteria: * Subjects should be otherwise healthy and not have any significant medical issues that could interfere with the study, in particular any heart arrythmias and not be on any prescription medications that could react with amitriptyline. * History of abnormal scarring (i.e., keloids) or poor wound healing. * No over the counter…
75mg amitriptyline
Placebo
Arctuva estimate
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