University of California, Los Angeles
This randomized, double-blind, placebo-controlled trial will compare magnesium glycinate, magnesium L-threonate, and placebo in UCLA varsity athletes. Participants will complete a baseline monitoring period followed by 4 weeks of blinded nightly supplementation. WHOOP 4.0 data will be used to evaluate sleep efficiency, total sleep time, sleep consistency, heart rate variability, resting heart rate, and recovery metrics. Baseline and final testing will assess selected reaction and physical performance outcomes. The primary outcome is change in WHOOP-derived sleep efficiency from baseline week to final treatment week.
Magnesium is involved in neuromuscular signaling, cellular energy metabolism, autonomic regulation, and sleep-related physiology. Competitive athletes often experience sleep restriction, training stress, travel, soreness, and recovery demands. Magnesium glycinate and magnesium L-threonate are commonly used athlete-facing magnesium formulations, but they are not interchangeable. Glycinate is commonly positioned as a well-tolerated sleep-oriented formulation, whereas L-threonate is of interest because of prior signals related to sleep, cognition, reaction performance, and central nervous system…
Inclusion Criteria: * Age 18-35 years. * Current NCAA Division I athlete at UCLA. * Actively participating in team training and/or competition. * Willing to wear a WHOOP 4.0 device continuously during the baseline and treatment periods of the study block. * Able to swallow oral capsules and follow supplement instructions. * Able and willing to complete daily REDCap surveys and weekly check-ins during the study block. * Fluent in English. * Able to provide informed consent. Exclusion Criteria: * Known kidney disease or impaired renal function, assessed by participant-completed screening ques…
Blinded oral magnesium glycinate, exactly two capsules nightly for 28 days. The nightly dose is 240 mg elemental magnesium by label claim (120 mg per capsule) and 288 mg by lot-specific assay (144 mg per capsule). Take approximately 1 hour before intended bedtime, with food, while upright, and with at least 8 oz water. No study product is taken during the 1-week baseline period.
Blinded oral magnesium L-threonate (Magtein), exactly two 1-g capsules nightly for 28 days, for 2 g Magtein and 156 mg elemental magnesium nightly based on the linked raw-ingredient assay of 7.8% magnesium. Take approximately 1 hour before intended bedtime, with food, while upright, and with at least 8 oz water. No study product is taken during the 1-week baseline period.
Matched oral placebo, exactly two capsules nightly for 28 days. Each capsule contains calcium laurate 300 mg plus silicified microcrystalline cellulose 440 mg and no active magnesium. Take approximately 1 hour before intended bedtime, with food, while upright, and with at least 8 oz water. No study product is taken during the 1-week baseline period. One matched-placebo regimen is used, without double-dummy.
Arctuva estimate
Actual pay is set by the research site.
Verify or correct the compensation shown for this listing.