A Randomized, Single-Blinded, Controlled Study Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
NYU Langone Health
Summary
This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics. All surgical created wounds for any hand surgery will be treated in a randomized fashion with the following four arms: 1. Bupivacaine + lidocaine 2. Bupivacaine + lidocaine + thrombin 3. Bupivacaine + lidocaine + thrombin + tranexamic acid 4. Bupivacaine + lidocaine + thrombin + aminocaproic acid All are applied topically to surgical bed prior to closure of skin.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 18 or older * Any patient undergoing elective hand surgery Exclusion Criteria: * Any patient with a traumatic or infected open wound (only surgically created wounds will be included) * History of chronic pain * History of narcotic addiction * History of recreational drug dependency * History of psychiatric pathology * Allergy or hypersensitivity to local anesthetics, recombinant human thrombin or tranexamic acid * History of coagulopathy or active thromboembolic disease * Any patient receiving a supra/infraclavicular block for anesthesia * Pregnancy * Hypersensitiv…
Interventions
- DrugBupivacaine
5 ml of 0.25% bupivacaine
- DrugLidocaine
5 ml of 1% lidocaine
- DrugThrombin
10000 units of thrombin
- DrugTranexamic acid
500 mg of tranexamic acid
- DrugAminocaproic acid
1000 mg of aminocaproic acid
Location
- NYU Langone HealthNew York, New York