Exploring the Interactive Effects of Sodium and Potassium Intake on Vascular Health in Older Adults
Florida State University
Summary
The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are: 1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults. 2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex. Participants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.
Description
Cardiovascular health declines with age, especially in postmenopausal females. High sodium diets are a major contributor to cardiovascular disease. Unfortunately, reducing sodium intake can be challenging. It is known that increasing potassium intake can improve cardiovascular disease risk factors in young adults, even if sodium intake remains high. The investigators are hoping to show that potassium can improve cardiovascular health in the context of a high sodium diets in older adults. In this study, participants will consume three 10-day controlled diets in a randomized order. The study die…
Eligibility
- Age range
- 55–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adults ages 55-75 years * At least one-year post-menopause (females) * Willing and able to attend laboratory visits Exclusion Criteria: * BMI ≥35 kg/m2 * Seated blood pressure \>135/85 mmHg * Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke) * Taking exogenous hormones or hormone replacement therapy * Following a vegan or gluten free diet * Significant weight loss (\>10% of body weight) in the last 6 months, or actively trying to lose weight * Current or recent use of a d…
Interventions
- Otherlow sodium/low potassium diet
On this intervention, participants will be given a diet that provides 2,000 mg Na/day and 2,000 mg K/day
- Otherhigh sodium/low potassium diet
On this intervention, participants will be given a diet that provides 4,700 mg Na/day and 2,000 mg K/day
- Otherhigh sodium/high potassium diet
On this intervention, participants will be given a diet that provides 4,700 mg Na/day and 4,700 mg K/day
Location
- Florida State UniversityTallahassee, Florida