Mathematical Modeling of Type 2 Diabetes Mellitus
Clinical Nutrition Research Center, Illinois Institute of Technology
Summary
This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions. The purpose of this study is to develop mathematical models and digital representations ("digital twins") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.
Description
Participants will first complete a screening visit at the Clinical Nutrition Research Center (CNRC) at the Illinois Institute of Technology. Screening procedures include assessment of medical history, dietary habits, physical activity history, body measurements, vital signs, glycated hemoglobin (HbA1c), and evaluation of eligibility criteria. Eligible participants will receive a continuous glucose monitor (CGM) and wearable activity tracker and will complete dietary recall assessments during the outpatient monitoring period. Participants will undergo approximately 8 days of outpatient monitor…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Men or women, 18-65 years of age * Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening * Current insulin therapy for ≥ 6 months prior to screening * Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months) * Judged to be in good health based on medical history (i.e., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease) * Able to provide informed consent * Able to comply with and perform the procedures requested by the protocol (including dietary restr…
Location
- Illinois Institute of TechnologyChicago, Illinois