Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

University of Missouri-Columbia

Summary

Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.

Eligibility

Age range: 18–65 years
Sex: All
Healthy volunteers: Yes

Detailed criteria

Inclusion Criteria: * 18 to 65 years of age Individuals with obesity and comorbid IR * BMI 30-45 kg/m2 * Waist circumference ≥102 cm (men) or ≥88 cm (women) * HOMA-IR ≥2.5 Healthy normal weight adults * BMI 18-25 kg/m2 * Waist circumference \<94 cm (men) and \<80 cm (women) * HOMA-IR \<2 Exclusion Criteria: * Pregnancy, breastfeeding * Unable to provide consent * Diabetes or polycystic ovarian syndrome * Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke * Nerve/neurologic disease * Uncontrolled hypertension (systolic blood…

Interventions

Drug
human insulin
Participants will be administered human insulin (160 IU) using an intra-nasal device.

Location

University of Missouri
Columbia, Missouri
limberglab@missouri.edu 573-882-2544

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Summary

Eligibility

Interventions

Location

Run this study?

Details

Conditions