Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
University of Missouri-Columbia
Summary
In the present study, we seek to determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 18 to 65 years of age Individuals with obesity and comorbid IR * BMI 30-45 kg/m2 * Waist circumference ≥102 cm (men) or ≥88 cm (women) * HOMA-IR ≥2.5 Healthy normal weight adults * BMI 18-25 kg/m2 * Waist circumference \<94 cm (men) and \<80 cm (women) * HOMA-IR \<2 Exclusion Criteria: * Pregnancy, breastfeeding * Unable to provide consent * Diabetes or polycystic ovarian syndrome * Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke * Nerve/neurologic disease * Uncontrolled hypertension (systolic blood…
Interventions
- Drughuman insulin
Participants will be administered human insulin (160 IU) using an intra-nasal device.
Location
- University of MissouriColumbia, Missouri