High-Dose Spaced Bilateral tDCS for Late-Life Depression: Open-Label Pilot Study
Andre Russowsky Brunoni
Summary
The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD). The study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered as three daily sessions, 3 times a week, for 3 weeks in older adults (60 y/o and older) with late-life depression.
Eligibility
- Age range
- 60+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Participants must meet all of the following criteria: 1. age 60 years or older; 2. diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Mini International Neuropsychiatric Interview (MINI); 3. score of 17 or higher on the 17-item Hamilton Depression Rating Scale (HDRS-17) at screening; 4. stable antidepressant regimen for at least four weeks prior to enrollment, if applicable; 5. capacity to provide informed consent; 6. Clinical Dementia Rating scale of 0 or 0.5. Ex…
Interventions
- DeviceHigh-intensity (6 mA) transcranial direct current stimulation (tDCS)
High-intensity (6 mA), spaced (three daily sessions, 3 times a week, for 3 weeks) transcranial direct current stimulation (tDCS) in older adults (60 y/o and over) with Late-Life Depression
Location
- University of Texas Southwestern Medical CenterDallas, Texas