Cannabis and Opioid Use Disorder, Study 2
University of Kentucky
Summary
This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks. During this time, we will examine how repeated doses of oral cannabis and acute doses of oral and inhaled cannabis 1) modify the intensity and time course of opioid withdrawal, 2) modify the effects of intranasal opioid administration and 3) impact the safety of opioid administration.
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Participants with moderate to severe opioid use disorder Exclusion Criteria: * Individuals who do not use opioids or do not experience opioid withdrawal when they stop using opioids
Interventions
- DrugOral Cannabis + Placebo
Participants will receive active and placebo oral cannabis
- DrugInhaled Cannabis
Participants will receive inhaled cannabis and placebo
- DrugIntransal Opioid
Participants will receive intranasal opioids and placebo
Location
- University of KentuckyLexington, Kentucky