Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
University of Missouri-Columbia
Summary
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
Eligibility
- Age range
- 18–70 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Healthy women, * Assigned female at birth, * 18-70 years of age, * Body mass index \<18 or ≥30 kg/m2, Exclusion Criteria: * Assigned male at birth, * Pregnancy, * Breastfeeding, * History of hormone replacement therapy, chemical menopause, or oophor-ectomy * Polycystic ovarian syndrome or Primary ovarian insufficiency, * Current smoking/Nicotine use, * Blood pressure ≥140/90 mmHg, * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy, * Nerve/neurologic disease, * Cardiovascular, hepatic, renal, respiratory disease, * Hypers…
Interventions
- DrugPlacebo
Participants will receive a placebo in pill form.
- DrugGemtesa
Participants will receive oral gemtesa (75 mg).
Location
- University of MissouriColumbia, Missouri