Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
University of Missouri-Columbia
Summary
We hypothesize vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
Eligibility
- Age range
- 18–70 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: Healthy women Assigned female at birth 18-70 years of age Body mass index \<18 or ≥30 kg/m2 Exclusion Criteria: Assigned male at birth Pregnancy Breastfeeding History of hormone replacement therapy, chemical menopause, or oophor-ectomy Polycystic ovarian syndrome or Primary ovarian insufficiency Current smoking/Nicotine use Blood pressure ≥140/90 mmHg Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy Nerve/neurologic disease Cardiovascular, hepatic, renal, respiratory disease Hypersensitivity to nitroglycerin Diabetes Commun…
Interventions
- DrugPlacebo
Participants will receive a placebo in pill form.
- DrugGemtesa
Participants will receive oral gemtesa (75 mg).
Location
- University of MissouriColumbia, Missouri