A Randomized, Double-Masked, Dose-Ranging Study of Atropine Sulfate Ophthalmic Solution for the Treatment of Symptoms of Epiphora
Rehan Ahmed
Summary
The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops. The main questions it aims to answer are: Do the eye drops reduce how often participants have watery eyes? What medical problems do participants have when taking the eye drops? Researchers will compare two strengths of the eye drops (0.005% and 0.01%) to see whether one works better than the other and whether the lower strength works as well as the higher one. Participants will: * Use the assigned eye drops in the affected eye(s) for one week * Visit the clinic twice for checkups and eye tests * Receive a follow-up phone call about two weeks after starting, to check on any symptoms
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
You may be able to join if you: * Are 18 years or older * Have vision of 20/200 or better in at least one eye * Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day * Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or both eyes * Have a healthy eye surface, with no significant dry eye, active eye infection, or active eye inflammation * Have adequate eyelid position and tone, where surgery is not the main treatment needed and reducing tear production is likely to h…
Interventions
- DrugAtropine ophthalmic solution
The interventions are two low doses of atropine ophthalmic solution
Locations (2)
- Greater Houston Eye ConsultantsHouston, Texas
- North Texas Eye SpecialistsMesquite, Texas