Virginia Polytechnic Institute and State University
A proof of concept case study to investigate accelerated LIFU protocol in chronic pain and anxiety populations.
A single-arm, open label, 2 cohort (chronic pain/GAD) case study with extended (6 months) follow-up following accelerated low-intensity focused ultrasound for neuromodulation.
Inclusion Criteria: * GAD Symptoms - GAD-7 score \>= 10, OASIS score \>= 8, or PSWQ score \>= 45. OR Chronic pain symptoms - moderate to severe pain, present for at least 3 months. Exclusion Criteria: * Claustrophobia * Contraindications to MRI or CT * Active medical disorder with CNS effects * History of neurologic disorder * History of head injury with LOC \> 10 minutes * Active drug or alcohol dependence
Low-Intensity Focused Ultrasound applied multiple times in a single study visit.
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