Virginia Polytechnic Institute and State University
This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.
This parallel 2 arm study is sham controlled and collected over 6 study visits. Participants will receive MRI and CT scans, LIFU neuromodulation, cognitive assessments, and questionnaires batteries to assess tolerability and functional outcomes in an MCI population.
Inclusion Criteria: * Montreal Cognitive Assessment (MoCA) scores between 18-23 inclusive, and able to consent to their own medical care. Exclusion Criteria: * Claustrophobia * MRI contraindications (pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, or other implants) * CT contraindications (pregnancy) * Non-AD etiology (eg. Lewy body disease, vascular dementia, alcohol/drug related damage) * Taking anti-amyloid antibodies * Neuromod within 6 months of the study * History of other neurological disorder * Hx of head injury with LOC \> 10 min * Active alcohol or d…
low-intensity focused ultrasound applied with a two element transducer from sonic concepts.
Blocked LIFU
Arctuva estimate
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