Collagenase Injection for Contracture and Spasticity Management
The University of Texas Health Science Center, Houston
Summary
The overall goal is to investigate the effectiveness of a novel intervention - Collagenase injection, for contracture management in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * ≥ 6 months post stroke, brain injury or spinal cord injury, medically stable; * clinical diagnosis of tendon contracture Exclusion Criteria: * Is hypersensitive to XIAFLEX or collagenase; * Is currently adjusting tone alternating medications (e.g., baclofen), or * Received botulinum toxin injection to target areas \<4 months, or phenol injections \< 9 months; * Received surgical release of tendons; * Is a pregnant woman; * Has coagulation disorders, including those who receive concomitant anticoagulants (except for low-dose aspirin). * has heritable connective tissue d…
Interventions
- BiologicalActive XIAFLEX Collagenase injection
Collagenase is an enzyme that breaks down collagen, which is a key component of connective tissue, such as fascia. XIAFLEX is an FDA-Approved collagenase for treatment of Dupuytren's contracture with a palpable cord in the fingers, and Peyronie's disease in the penile tissue. In this research project, we plan to use collagenase to treat contracture in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury. FDA guidelines will be followed for dosing and patient selection to minimize or reduce the risks.
Location
- The University of Texas Health Science Center at HoustonHouston, Texas