Delirium Evaluation With Longitudinal Tau Assessment
Scripps Health
Summary
The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive care unit (ICU). The main question DELTA aims to answer is: Can digital biometrics predict and detect delirium in older adult ICU patients? Do biomarkers of neurodegeneration fluctuate in ICU patients in such a way that delrium could potentially be predicted? Participants admitted o the ICU will wear a digital device to collect biometric data and will have serial plasma samples collected during ICU admission and patients will be also assessed for delirium daily by study staff.
Eligibility
- Age range
- 65+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Admitted to the intensive care unit * Able to consent or have a legally authorized representative consent on their behalf * English speaker * Expected ICU stay of 48 hours or more Exclusion Criteria: * Advanced dementia * End stage liver disease * Renal replacement therapy * Structural brain injury, including but not limited to traumatic brain injury, cerebrovascular accident and intracranial hemorrhage,
Locations (2)
- Scripps Green HospitalLa Jolla, California
- Scripps Memorial La Jolla HospitalSan Diego, California