Lung Health and Breath Biomarkers: Acute Effects of Combusted and Vaporized Cannabis Inhalation Compared to Tobacco Cigarette Combustion in the Human Laboratory
Hannah Harris
Summary
This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. English-speaking, 2. Literate adults, 3. Male or female, 4. Between the ages of 18 and 55, 5. Body Mass Index from 18.5 and 32.0 kg/m2, 6. Able to provide written informed consent and perform all study procedures, 7. Current recreational cannabis users - must report past 30-day cannabis use and at least 5 exposures in the past year (minimum use criteria); no limit on maximum use, 8. Past year history of vaporized or smoked cannabis use to intoxication, 9. Past 30-day use of combusted tobacco, 10. Not currently seeking treatment for cannabis, tobacco cigarettes, or other…
Interventions
- DrugCannabis (THC)
Active Cannabis (THC) will be inhaled.
- DrugTobacco Cigarette
A leading brand of tobacco cigarette (\~1.0 gram; Marlboro Gold; Phillip Morris International)
Location
- University of KentuckyLexington, Kentucky