Metformin and Muscle Recovery Following ACL Surgery
University of Utah
Summary
The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength. ACL injury and surgery increase muscle collagen content and inflammation which slows the recovery of muscle and function and ultimately impacts the quality of life. Individuals enrolled in the study will be randomized to receive metformin (or placebo) for 4 months after surgery. The investigators will measure muscle strength and inflammatory markers in muscle biopsy samples after the intervention period. Investigators will also follow up with participants 8 months later to determine the lasting effects of the intervention.
Eligibility
- Age range
- 40+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age between 40y and older 2. BMI: \<30 kg/m2 3. Full thickness ACL tear 4. Less than 6 months between ACL injury and scheduled ACLR Exclusion Criteria: 1. Prior ACL tear in limb scheduled for reconstruction or current bilateral ACL tear 2. Total knee dislocation 3. Anticipated quadriceps ACLR grafts 4. Current infection near the lower limb 5. Inability to attend physical therapy sessions 6. Post-operative loading restrictions 7. History of cardiovascular disease (e.g., CHF, CAD, MI, CVA) 8. History of endocrine or metabolic disease such as hypo/hyperthyroidism and dia…
Interventions
- DrugMetformin
Individuals randomized to the metformin group will take metformin daily (up to 2grams/day) for 4 months following ACLR surgery.
- OtherPlacebo
Individuals randomized to the placebo will take the same number of pills as the metformin group daily over a 4 month period following ACLR surgery.
Location
- University of UtahSalt Lake City, Utah