Cognitive and Motor Function Examination in Patients With Urea Cycle Disorders (UCD) During a Driving Task Using Functional Near Infrared Spectroscopy (fNIRS)
St. Jude Children's Research Hospital
Summary
This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and attention.
Description
Primary Objective * To use fNIRS to study brain functional behavior in subjects with UCD by measuring the changes in HbO, HbR and HbT concentrations versus healthy control volunteers during the baseline driving task on the left and right prefrontal cortex (LPFC, RPFC). Secondary Objective * To include other cortical regions such as temporal and occipital regions, to investigate the neurocognitive changes in these regions which may or may not change with driving. Thus, we will measure changes in HbO, HbR and HbT concentrations during the baseline driving task in four more brain regions (left…
Eligibility
- Age range
- 16–40 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Individuals 16 to 40 years with molecular or biochemical confirmation of a urea cycle disorder. * Healthy individuals will serve as an age and sex matched comparison group. Active driver's license for at least 6 months * Read and understand English. as the tasks have not been validated in other languages * IQ \>=70. Exclusion Criteria: * Skin disease that affects the scalp * Past or present vascular disease * Head trauma with loss of consciousness in the last year or evidence of cognitive impairment due to and persisting after head trauma * Motor movement disorder whic…
Location
- St. Jude Children's Research HospitalMemphis, Tennessee