Dorsal Root Electrical Stimulation to Suppress Spastic Muscle Activation in Children With Cerebral Palsy
Martin Piazza
Summary
The goal of this clinical trial is to evaluate whether dorsal root electrical stimulation could reduce spasticity in children with cerebral palsy (CP).
Description
The investigators will recruit participants with CP requiring selective dorsal rhizotomy (SDR) surgery. During SDR, spastic dorsal roots are routinely identified by electrically stimulating each root at low frequency (1 Hz) and measuring the resulting muscle response via electromyography - a procedure called "clinical test stimulation." Dorsal roots that produce an abnormally large and widespread compound muscle action potential (CMAP) are classified as spastic. In this study, the investigators will superimpose higher-frequency dorsal root stimulation (40-5000 Hz) on top of this standard clini…
Eligibility
- Age range
- 3–14 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Children ages 3 to 14 * Diagnosis of Cerebral Palsy * Require an SDR as determined by the multidisciplinary movement disorders team * Confirmation that subjects' terms of insurance coverage for their standard of care procedure will not be altered by study enrollment. Exclusion Criteria: * No exclusion criteria
Interventions
- DeviceConstant Current Stimulator
The DS8R is an external isolated stimulator system used in human research (DS8R), delivers controlled electrical pulses with adjustable stimulation parameters.
- DeviceCadwell Guardian System
The Cadwell Guardian System is a clinical intraoperative system used to deliver stimulation in the dorsal root during SDR.
Location
- UPMC Children's Hospital of PittsburghPittsburgh, Pennsylvania