A Prospective Study of Low Dose Radiotherapy for Osteoarthritis
Abramson Cancer Center at Penn Medicine
Summary
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Description
To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 18 years or older * Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows. * Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired. * Provision of signed and dated informed consent. Exclusion Criteria: * Unable to reasonably complete study instruments.
Interventions
- RadiationLow Dose Radiation Therapy
Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.
Locations (2)
- Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania
- Perelman Center for Advanced MedicinePhiladelphia, Pennsylvania