A Phase 1, Single-dose, Open-label Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Adagrasib (BMS-986503) in Healthy Participants of Japanese Descent
Mirati Therapeutics Inc.
Summary
The aim of this study is to assess the pharmacokinetics, safety and tolerability of single-dose Adagrasib (BMS-986503) in healthy participants of Japanese descent
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Participants must be of Japanese descent (both biological parents of the participant are ethnically Japanese). * Participants must be healthy adult without clinically significant deviation from normal in medical history, PE, 12-lead ECG, vital sign measurements, and clinical laboratory assessments as determined by the investigator. * Participants must have Body mass index of 18.0 kg/m2 to 32.0 kg/m2. * Participants must have Total body weight ≥ 50 kg. Exclusion Criteria: * Participants must not have significant history or clinical manifestation of any metabolic, allerg…
Interventions
- DrugAdagrasib
Specified dose on specified days
Location
- Local Institution - 0001Anaheim, California