Combating Age-related Failure of Myelination in Multiple Sclerosis: an Exploratory Study
University of Washington
Summary
This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.
Description
The primary aim of this study is to explore clinical variables and potentially modifiable risk factors that are associated with improved myelination (both enhanced remyelination and reduced demyelination) in older adults living with multiple sclerosis. The emphasis here will be on discovery and generation of pilot data to support further definitive longitudinal observational studies, and ultimately, clinical trials on behavioral and/or pharmaceutical interventions to prevent demyelination and promote remyelination in people living with MS. Participants will be categorized based on whether the…
Eligibility
- Age range
- 50–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of multiple sclerosis * Independent with ambulation (able to walk 500m without aid) * Disease duration \>10 years * Age 50 to 70 years (inclusive) * Be able to read, speak, and understand English Exclusion Criteria: * Diagnosis of other neurologic disease that would interfere with interpretation such as stroke, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica (NMO), and sarcoidosis. * Inability to complete study procedures (including obtaining MRI at BMIC and using Fitbit connected to smartphone) * Currently partic…
Interventions
- OtherObservation
No intervention is administered. Participants undergo observational assessments including MRI, wearable activity monitoring, and questionnaires.
Location
- Multiple Sclerosis Center at UW Medical Center - NorthwestSeattle, Washington