A Multicenter Phase 2 Study of Luspatercept in Patients With Anemia Due to Chronic Kidney Disease
Memorial Sloan Kettering Cancer Center
Summary
The researchers are doing this study to test whether luspatercept works to improve hemoglobin levels in people with anemia caused by chronic kidney disease (CKD). The researchers will also test whether luspatercept is a safe treatment that causes few or mild side effects in participants.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Documentation of Anemia due to CKD * Patients must have a Hb ≤ 9.5 g/dL on two separate occasions within 4 weeks prior to enrollment. * Do not anticipate red cell transfusion within the following 4 weeks and no history of red cell transfusion in three weeks prior to enrollment. * Ferritin ≥100 ng/mL and iron transferrin saturation (TSAT) ≥ 20%. * Serum folate \> 4 ng/mL * Serum vitamin B12 \> 250 pg/mL * Patients may have received iron, B12 and folic acid repletion if initiated \> 6 weeks prior to enrollment. Patients who are already on iron, B12 and folic acid repletion…