Pilot Study of Fermented Papaya Preparation (FPP) Impact on Transepidermal Water Loss of Skin on Face, Arms, and Hands
University of Pittsburgh
Summary
This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands. Areas of diminished barrier function are defined as those not visible to the eye but identified as areas of high transepidermal water loss (TEWL) as measured by a non-invasive pen-like device. A TEWL value of 20 or higher at a location would be considered high TEWL. Participants will attend 5 visits over 20 weeks, with 12-weeks of FPP treatment, and 8-weeks of follow-up.
Eligibility
- Age range
- 50–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. 50-75 years 2. Willing to allow collection of 3 blood samples (Baseline, Week 12 and Week 20) 3. Willing to log daily compliance with FPP intake during the study period (12 weeks) 4. Absence of active systemic disease per investigator judgement. 5. No current use of immunosuppressant or immunomodulatory medications. 6. No active dermatological conditions at measurement sites that could impair measure, per investigator judgement. 7. Investigator determination of general good health. Exclusion Criteria: 1. Co-morbidity or concurrent medication that the Investigator deem…
Interventions
- Dietary SupplementFermented Papaya Preparation (FPP)
Immun'Age Fermented Papaya Preparation
Location
- McGowan Institute for Regenerative MedicinePittsburgh, Pennsylvania