Haloperidol For Outpatient Symptom Management in Patients Diagnosed With Cannabinoid Hyperemesis Syndrome in the Emergrency Department
University of Illinois at Chicago
Summary
Patients diagnosed with cannabinoid hyperemesis syndrome that are safe for discharge from the emergency department will be sent an outpatient prescription for haloperidol to be used as needed at home. The study goal is to see if having this medication available helps to prevent return emergency department visits for recurrent or persistent symptoms.
Description
Cannabinoid hyperemesis syndrome is a relatively new syndrome characterized by nausea, vomiting, and abdominal pain in the setting of excessive cannabis use. This clinical entity has become increasingly prevalent as the concentration of THC has increased in marijuana products over the past several decades. The symptoms have been treated successfully with several medications however the most efficacious appears to be dopamine antagonists such as haloperidol and droperidol. These dopamine antagonists have been used safely and successfully in the inpatient and emergency department settings to dec…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Patients who meet ROME-4 diagnostic criteria for cannabinoid hyperemesis syndrome Exclusion Criteria: Already on dopamine agonist/antagonist therapy for another condition Parkinson's disease Lewy body dementia Men with QTc \> 450 Women with QTc \> 460 Patients with documented allergy to haloperidol Patients with known functional prolactinomas Patients who are breastfeeding Patients under the age of 18 Patients who are pregnant Patients who are in the prison system Patients who are unable to consent
Interventions
- DrugHaloperidol
This intervention involves providing patients an outpatient prescription for as needed haloperidol to attempt to control symptoms of cannabinoid hyperemesis and to attempt to prevent return to the emergency department for that reason.
Location
- University of Illinois HospitalChicago, Illinois