Massachusetts General Hospital
This study will compare the effect of orforglipron and phentermine on weight maintenance.
Inclusion Criteria: 1. Age 18-80 years at screening 2. History of BMI ≥30 kg/m² 3. Current or recent (within 8 weeks) treatment with injectable semaglutide, tirzepatide, or similar GLP-1 based medication 4. Achieved ≥10% body weight loss since initiation of injectable semaglutide, tirzepatide or similar GLP-1 based medication 5. Willing to participate in the study after reviewing study infographic and confirming understanding of randomization and study procedures 6. Ability to understand and the willingness to sign a written informed consent document 7. Residence in Massachusetts Exclusion C…
Phentermine 8 mg or 37.5 mg tablet
orforglipron 0.8, 2.5, 5.5, 9, 14.5 or 17.2 mg tablets
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