Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1-based Therapy Discontinuation
Massachusetts General Hospital
Summary
This study will compare the effect of orforglipron and phentermine on weight maintenance.
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 18-80 years at screening 2. History of BMI ≥30 kg/m² 3. Current or recent (within 8 weeks) treatment with injectable semaglutide, tirzepatide, or similar GLP-1 based medication 4. Achieved ≥10% body weight loss since initiation of injectable semaglutide, tirzepatide or similar GLP-1 based medication 5. Willing to participate in the study after reviewing study infographic and confirming understanding of randomization and study procedures 6. Ability to understand and the willingness to sign a written informed consent document 7. Residence in Massachusetts Exclusion C…
Interventions
- DrugPhentermine Pill
Phentermine 8 mg or 37.5 mg tablet
- DrugOrforglipron
orforglipron 0.8, 2.5, 5.5, 9, 14.5 or 17.2 mg tablets
Location
- Massachusetts General HospitalBoston, Massachusetts