Comparison of Immune Response Following Posterior Spinal Fusion in Patients With Idiopathic vs. Neuromuscular Scoliosis
Ambrish Patel
Summary
The objective of this study is to evaluate the immune response to posterior spinal fusion (PSF) in patients with neuromuscular scoliosis, comparing patients with idiopathic scoliosis who undergo the same procedure. This will be accomplished using serum biomarkers of immune response. Anecdotally, it appears that patients with neuromuscular scoliosis have more fluid resuscitation needs compared to patients with idiopathic scoliosis. The proposed hypothesis of this observation is that patients with neuromuscular scoliosis have a more profound immune response compared to patients with idiopathic scoliosis, which leads to a more robust systematic inflammatory response syndrome.
Description
The primary endpoint is to evaluate serum immune profile assays obtained pre-operatively and post-operatively comparing patients with neuromuscular scoliosis to those with idiopathic scoliosis undergoing posterior spinal fusion. This will be done by obtaining a blood sample prior to incision in the operating room and one when the patient is in the PACU, prior to leaving. In the event that the patient is directly admitted to the pediatric intensive care unit (PICU), a sample will be obtained there. As part of standard of care, patients undergoing PSF have a peripheral arterial lane placed for i…
Eligibility
- Age range
- 0–99 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Any patient undergoing a posterior spinal fusion, regardless of age (birth to adult) * any patient with a diagnosis of idiopathic or neuromuscular scoliosis Exclusion Criteria: * Patient taking immunomodulators (monoclonal antibodies, chemotherapeutic agents) * chronic steroid use
Interventions
- Diagnostic TestSerum blood samples for serum biomarkers of immune response
Preoperative and postoperative blood samples using biomarkers to evaluate immune response.
Location
- Nationwide Children's HospitalColumbus, Ohio