Dietary Supplementation With EVOO Phenolics Prevents MCI Progression to Alzheimer's Disease
Augusta University
Summary
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are: * Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways? Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics) Participants will: * Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.
Eligibility
- Age range
- 50–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25. Exclusion Criteria: * History or presence of vascular disease that may affect cognitive function * History or presence of stroke within the past 1 year * Recent transient ischemic attack (TIA) within the past 180 days * History of severe, clinically significant CNS trauma * History of intracranial tumor * History or presence of kidney disease (eGFR \<60 mL/min/1.73m2) * Presence of a pacemaker * Presence of metal in the body * Allergic to the MRI contrast agent "Multihan…
Interventions
- Dietary SupplementEVOO-phenolics dietary supplement
EVOO phenolic dietary supplement which is standardized to contain10 mg of EVOO total phenolics
- Dietary SupplementPlacebo
Placebo
Location
- Georgia prevention instituteAugusta, Georgia