Developing Biomarker-Supported SSD Prevention
The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns
Eligibility
- Age range
- 9–19 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and/or parent/legal guardian report and confirmed by a structured interview * screening positive for two or more risk factors targeted by the intervention * Participants and parent(s)/legal guardian(s) agree to participate * psyc…
Interventions
- BehavioralPsychosocial intervention group
Over 16 weeks, participants and their parent/legal guardian(s)/caregiver(s) will attend weekly hour long family-based psychosocial intervention to work on their top 2 modifiable SSD-risk factors targeted by the risk reduction therapy (RRT)
Location
- The University of Texas Health Science Center at HoustonHouston, Texas