A Pilot Study for Managing Depressive Symptoms in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Mayo Clinic
Summary
The purpose of this research is to evaluate the feasibility and effectiveness of Digital Neurotherapy (DNT) or Capacity Coaching (CC) for managing symptoms of depression and self reported pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to education alone.
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria: * Confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria * Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR \>10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months) * Clinical or self-diagnosis of depression * English-language fluency Exclusion criteria: * Suicidal ideation/unstable mental illness of any kind * Lack of access/ability to use internet-based programs * eGFR \<10 ml/min/1.73m2 * Anticipated dialysis or transplant within 6 months * Prior chronic dialysis * Prior organ (liver or kidney) transplant * Lack of English langua…
Interventions
- BehavioralMayo Clinic-Approved Education
Education attention control will be administered by board certified health and wellness coaches via virtual coaching sessions.
- BehavioralDigital Neuropathy
The web-based system (REJUVENATE) consists of a set of cognitive exercises continuously and automatically adjusted in difficulty based on each user's performance to maintain the balance of challenge and success optimal to promote neuroplastic enhancement of target neural systems.
- BehavioralCapacity Coaching
Board certified health and wellness coaches will create a plan with subjects to use capacity, defined as patients' abilities and resources, to do self-management work.
Location
- Mayo ClinicRochester, Minnesota