Stroke volUme-baSed Fluid resusciTAtIoN in AP (SUSTAIN)
University of Southern California
Summary
The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.
Description
The proposed SUSTAIN Trial Study (Stroke volUme-baSed fluid resuscitation), a multi-center randomized controlled trial which will address these knowledge gaps in acute pancreatitis. Recently demonstration from the WATERFALL (Early Weight-Based Aggressive vs. ModeraTE Goal-DiRected Fluid ResuscitAtion) randomized controlled trial that aggressive hydration increased the risk of fluid overload without improving the clinical course of AP compared with a moderate hydration strategy. With further suggestions, rather than a generic body weight-based approach, tailoring fluid requirements to changes i…
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients between the age of 18-75 * Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment Exclusion Criteria: * Patients with the inability to preform a straight leg raise (i.e amputation) * Patients with high risk of adverse event related to fluid resuscitation * NYHA Class \>= II Heart Failure * Child's B and C Cirrhosis * Dialysis Requirement * Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites * Ag…
Interventions
- OtherLactated Ringer's
lactated ringer's in intervention is dosed based on changes in stroke volume versus a weight based strategy
- OtherLactated Ringers Stroke Volume Based Dosing
Lactated Ringers Rate is based on changes in stroke volume
Locations (2)
- University of Southern CaliforniaLos Angeles, California
- Ohio State UniversityColumbus, Ohio