The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
Applied Science & Performance Institute
Summary
This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol/day). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below). Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing. After the 8-week supplementation period (\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).
Description
On the day of testing, we will instruct subjects to avoid high-intensity, muscle-damaging exercise for a minimum of 72-hours prior to the visit, and avoid caffeine and alcohol 12 hours prior to each study visit, and during the testing visit itself. After a minimum 8-hour overnight fast, subjects will proceed with a series of tests in the following successive order: (1) Vital Signs (heart rate, blood pressure), followed by the POMS and Subjective Vitality Scale (SVS). (2) DXA for body composition, followed by consumption of a standardized food bar snack, and at least a 15-minute break after the…