The University of Texas Health Science Center, Houston
The purpose of this study is clinical and mycological clearance of onychomycosis using photodynamic therapy (PDT) with aminolevulinic acid (ALA) 10% gel at 6 months, 3 months, 9 months and 12 months
Inclusion Criteria: * Clinical and mycological diagnosis \[by potassium hydroxide (KOH) stain\] of onychomycosis Exclusion Criteria: * Known or suspected allergies or sensitivities to any components of any of the study drugs * Patients with coagulation disorders * Known or suspected claustrophobia * Pregnancy during the treatment period * Medically unable to consent * Employees of the clinics * Prisoners
ALA 10% gel will be applied under occlusion for 3 hours before PDT
Participants will have illumination on the affected nail with RhodoLED® XL 635 nm red light at 37 J/cm² at 5 inches for 13.5 minutes.
Participants will have 20% urea applied to affected nail daily for 2 weeks before start of treatment
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