Patrick Lao
The purpose of this study is to further engage and characterize Alzheimer's Disease Research Center (ADRC) participants through additional research opportunities, particularly PET imaging. Amyloid and Tau PET imaging will be collected in 24 participants per year, for a total of 120 participants over five years. All participants will be followed longitudinally, including through potential transitions from normal aging to mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD).
This study is a PET imaging component of the broader Alzheimer's Disease Research Center (ADRC) Clinical Core being conducted at Columbia University Irving Medical Center and is designed to further characterize ADRC participants through amyloid and tau PET imaging. The PET component supports the broader ADRC goals of maintaining a well-characterized, diverse longitudinal cohort across the spectrum of normal aging, mild cognitive impairment (MCI), and Alzheimer's disease and related dementias (ADRD), and facilitating collaborative research on cognitive aging and ADRD. Participants in this stud…
Inclusion Criteria: * Enrolled in the Alzheimer's Disease Resource Center (ADRC) * With or without memory problems or impairment * Able to participate in all scheduled evaluations and to complete all required tests and procedures in either English or Spanish. * In the opinion of the PI, the participant must be considered likely to comply with the study protocol and to have a high probability of completing the study. Exclusion Criteria: * Conditions precluding entry into the scanners (e.g., morbid obesity, claustrophobia, etc.) * Pregnant and/or breastfeeding * In the opinion of the PI, the…
MK-6240 is experimental but has been used in several human studies before and has been proven to accurately measure tau in the brain.
Florbetaben has been approved by the FDA to help diagnose Alzheimer's disease. Florbetaben measures amyloid in the brain.
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