Felipe Fregni, MD, PhD, MPH
This study will compare different treatment schedules of combined transcranial direct current stimulation (tDCS) and transcranial ultrasound stimulation (TUS) in participants with Parkinson's disease. Participants will be randomly assigned to one of four groups: Standard (10 sessions delivered five times per week for two weeks), Distributed (six sessions delivered three times per week for two weeks), Short (five sessions delivered over one week), or Sham (10 sham sessions delivered five times per week for two weeks).
Inclusion Criteria: 1. Diagnosis of idiopathic PD with self-reported balance impairment or postural instability. 2. Age 40 to 85 years. 3. Have at least moderate motor impairment (defined by minimum UPDRS Part III (motor) score of 20 while ON medication state). 4. On stable Parkinson's disease medications for at least 30 days prior to enrollment, based on self-report. Dose changes of up to 20% in dopaminergic medications during this period are considered stable. Exclusion Criteria: 1. Early or advanced stages of disease progression as defined by the modified Hoehn and Yahr stages scores of…
This study will compare different treatment schedules of combined transcranial direct current stimulation (tDCS) and transcranial ultrasound stimulation (TUS) in participants with Parkinson's disease.
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