A Pilot Study of Focal Magnetic Resonance (MR)-Guided Stereotactic Body Radiation Therapy (SBRT) for Prostate Cancer
City of Hope Medical Center
Summary
This clinical trial studies the side effects and how well magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) works in treating patients with prostate cancer. SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. MR-guided SBRT uses magnetic resonance imaging (MRI) to define and localize the area to be treated, which may help provide more accurate delivery of SBRT and lower side effects. MR-guided SBRT may be safe, tolerable, and/or effective in treating patients with prostate cancer.
Description
PRIMARY OBJECTIVE: I. To determine the safety of performing focal MR-guided SBRT. SECONDARY OBJECTIVES: I. To assess the tolerability of focal MR-guided SBRT. II. To characterize changes in urinary, bowel and sexual function in patients receiving focal MR-guided SBRT. III. To characterize changes in prostate symptoms in patients receiving focal MR-guided SBRT. IV. To characterize changes in sexual health in patients receiving focal MR-guided SBRT. V. To estimate the rate of biochemical recurrence after receiving focal MR-guided SBRT. VI. To estimate the rate of in-field prostate recurre…