Identifying Multidimensional Signatures of Gastric Interoception in Functional Dyspepsia
Massachusetts General Hospital
Summary
This study is being conducted to investigate gut-brain communication in individuals with functional dyspepsia and anorexia nervosa. The hope is that what the investigators learn from this study will improve the understanding the conditions better to improve treatments.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Participant Inclusion Criteria-- Functional Dyspepsia Group: * Males and females; ages 18-65 years * Rome V functional dyspepsia post-prandial distress syndrome subtype * Negative upper endoscopy or upper GI series to rule out structural/organic cause for FD * greater than or equal to 5.5 gut interoceptive awareness score (by VSI awareness subscale) * Fluent in English * Willing and able to provide informed consent * Stable dose for 30 days prior to Visit 1 if on a neuropsychiatric medication (e.g., TCA, SNRI, SSRI mirtazapine, atypical antipsychotic, gabapentin, buspirone, pregabalin) * No…
Interventions
- OtherFunctional magnetic resonance imaging (fMRI)
Pineapple pudding snack, with pre- and post-snack fMRI
Location
- Massachusetts General HospitalBoston, Massachusetts