Imaging Brain Energy Use in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study
Rajesh Narendran
Summary
Studies proposed in this application will image mitochondrial Complex-I in cocaine use disorder (CUD) and matched healthy controls
Description
This study uses \[18F\]BCPP-EF positron emission tomography (PET) to image mitochondrial complex-I in subjects with cocaine use disorder (CUD) and healthy controls (HC). Correlating PET outcome measures with relapse to cocaine in this study will clarify the mechanisms by which abnormal brain energetics modulate addictive behaviors. This study is supported by "the NIH The Helping to End Addiction Long-term® Initiative, HEAL Initiative (https://www.nih.gov/heal)"
Eligibility
- Age range
- 18–45 years
- Sex
- All
- Healthy volunteers
- Yes
Cocaine use disorders (CUD) 1. Males or females between 18 and 45 years old. 2. fulfill DSM-5 criteria for moderate or severe (4+ criteria) cocaine use disorder. 3. No lifetime DSM-5 schizophrenia, schizoaffective disorder, bipolar disorder, and developmental disorders. 4. No comorbid DSM-5 major depressive or severe anxiety disorders (including cocaine-induced mood and anxiety disorders) in the past 12 months. 5. No comorbid DSM-5 alcohol, opioids, sedative-hypnotics, hallucinogens, and inhalant use disorders in the past 12 months. Subjects with a moderate to severe DSM-5 cannabis use disord…
Interventions
- Drug[F-18]BCPP-EF
Radiotracer
Location
- University of PittsburghPittsburgh, Pennsylvania